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A Multiattribute-utility-function Approach to Weighing the Risks and Benefits of Pharmaceutical Agents

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  • Stuart Eriksen
  • L. Robin Keller

Abstract

Both the selection of doses of pharmaceutical agents and comparisons between pharma ceutical agents have long been based on the nonquantified concept of the risk-benefit ratio. Though useful, this concept implies a data comparison that is difficult to make: the toxicity versus the efficacy of a drug compound. This research demonstrates an approach for weigh ing risks and benefits by combining utility functions for human efficacy and toxicity with animal and laboratory toxicity information to develop an overall multiattribute utility function for an ophthalmic pharmaceutical agent, I-bunolol, intended for the treatment of glaucoma. With this multiattribute function and a small portion of the published data available for this drug, the expected utilities for six doses (including a control) could be compared and the value of this approach in drug-dosage selection demonstrated. Key words: decision analysis; expected utility; dosage selection; compound comparison; pharmaceutical decision; mul tiattribute utility; risk-benefit ratio. (Med Decis Making 1993;13:118-125)

Suggested Citation

  • Stuart Eriksen & L. Robin Keller, 1993. "A Multiattribute-utility-function Approach to Weighing the Risks and Benefits of Pharmaceutical Agents," Medical Decision Making, , vol. 13(2), pages 118-125, June.
    • Handle: RePEc:sae:medema:v:13:y:1993:i:2:p:118-125
    DOI: 10.1177/0272989X9301300205
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    References listed on IDEAS

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    1. Ralph L. Keeney & Rakesh K. Sarin & Robert L. Winkler, 1984. "Analysis of Alternative National Ambient Carbon Monoxide Standards," Management Science, INFORMS, vol. 30(4), pages 518-528, April.
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    Cited by:

    1. Bleichrodt, Han, 1995. "QALYs and HYEs: Under what conditions are they equivalent?," Journal of Health Economics, Elsevier, vol. 14(1), pages 17-37, May.

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