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Cognitive Function and Quality of Life in Interferon Therapy for Melanoma

Author

Listed:
  • Catherine M. Bender
  • Joyce M. Yasko
  • John M. Kirkwood
  • Christopher Ryan
  • Jacqueline Dunbar-Jacob
  • Thomas Zullo

    (University of Pittsburgh)

Abstract

The purpose of this pilot study was to describe short and long-term changes in cognitive function and quality of life in patients with melanoma receiving interferon (IFN) -2b. This study used a three-group, repeated measures design in which cognitive function and quality of life were evaluated prior to initiation of treatment at 3-month intervals during treatment and 3 months following the completion of treatment. The sample consisted of 16 adults with Stage II or III melanoma, randomized to one of three treatment groups. Participants in Arm A received high-dose IFN -2b, those in Arm B received low-dose IFN • -2b, and those in Arm C received no therapy (control). No significant changes in cognitive function were detected. In participants in ArmA, there was a significant deterioration in the physical well-being dimension of quality of life from baseline to 3 months after beginning therapy .

Suggested Citation

  • Catherine M. Bender & Joyce M. Yasko & John M. Kirkwood & Christopher Ryan & Jacqueline Dunbar-Jacob & Thomas Zullo, 2000. "Cognitive Function and Quality of Life in Interferon Therapy for Melanoma," Clinical Nursing Research, , vol. 9(3), pages 352-363, August.
    • Handle: RePEc:sae:clnure:v:9:y:2000:i:3:p:352-363
    DOI: 10.1177/10547730022158537
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