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Overlapping Community Detection on a Graph of Chemicals, Diseases and Genes for Drug Repositioning and Adverse Reactions Prediction

Author

Listed:
  • Maria Elena Garcia Ochagavia

    (Universidad de La Habana)

  • Yudivian Almeida Cruz

    (Universidad de La Habana)

  • Suilan Estevez Velarde

    (Universidad de La Habana)

  • Aimee Alonso Reina

    (Universidad de La Habana)

  • Maria Elena Ochagavia Roque

    (Centro de Ingenieria Genetica y Biotecnologia)

Abstract

Developing a drug from scratch is a very long and expensive process that has a small probability of success. For this reason, pharmaceutical companies are devoting their efforts to find drugs that could be repositioned. When using a drug to treat a disease is necessary to consider what adverse reactions it may cause, this is why the prediction of adverse reactions is highly related to drug repositioning. We propose the detection of overlapping communities over a biological network of chemicals, diseases and genes in order to find drug-disease pairs that could be used as basis for later drug repositioning and adverse reactions prediction analysis. Of the evaluated overlapping community detection algorithms, OSLOM got the best results, producing 724 communities from which was possible to extract 215944 drug-disease pairs not present in the analyzed graph. We illustrate the usefulness of this set through examples of associations between pairs found in the scientific literature.

Suggested Citation

  • Maria Elena Garcia Ochagavia & Yudivian Almeida Cruz & Suilan Estevez Velarde & Aimee Alonso Reina & Maria Elena Ochagavia Roque, 2019. "Overlapping Community Detection on a Graph of Chemicals, Diseases and Genes for Drug Repositioning and Adverse Reactions Prediction," Revista Internacional de Gestión del Conocimiento y la Tecnología (GECONTEC), Revista Internacional de Gestión del Conocimiento y la Tecnología (GECONTEC), vol. 7(2), pages 80-96, November.
    • Handle: RePEc:rge:journl:v:7:y:2019:i:2:p:80-96
    DOI: 138
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    More about this item

    Keywords

    Drug repositioning; adverse reactions; overlapping community detection; biological network;
    All these keywords.

    JEL classification:

    • M1 - Business Administration and Business Economics; Marketing; Accounting; Personnel Economics - - Business Administration
    • M15 - Business Administration and Business Economics; Marketing; Accounting; Personnel Economics - - Business Administration - - - IT Management
    • O3 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights
    • O31 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Innovation and Invention: Processes and Incentives
    • O32 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Management of Technological Innovation and R&D
    • D8 - Microeconomics - - Information, Knowledge, and Uncertainty
    • D81 - Microeconomics - - Information, Knowledge, and Uncertainty - - - Criteria for Decision-Making under Risk and Uncertainty

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