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Serum miR-192-5p levels predict the efficacy of pegylated interferon therapy for chronic hepatitis B

Author

Listed:
  • Yoshihito Nagura
  • Kentaro Matsuura
  • Etsuko Iio
  • Koji Fujita
  • Takako Inoue
  • Akihiro Matsumoto
  • Eiji Tanaka
  • Shuhei Nishiguchi
  • Jong-Hon Kang
  • Takeshi Matsui
  • Masaru Enomoto
  • Hiroki Ikeda
  • Tsunamasa Watanabe
  • Chiaki Okuse
  • Masataka Tsuge
  • Masanori Atsukawa
  • Masakuni Tateyama
  • Hiromi Kataoka
  • Yasuhito Tanaka

Abstract

We examined the association between serum miRNA (-192-5p, -122-3p, -320a and -6126-5p) levels and the efficacy of pegylated interferon (Peg-IFN) monotherapy for chronic hepatitis B (CHB) patients. We enrolled 61 CHB patients treated with Peg-IFNα-2a weekly for 48 weeks, of whom 12 had a virological response (VR) and 49 did not VR (non-VR). A VR was defined as HBV DNA

Suggested Citation

  • Yoshihito Nagura & Kentaro Matsuura & Etsuko Iio & Koji Fujita & Takako Inoue & Akihiro Matsumoto & Eiji Tanaka & Shuhei Nishiguchi & Jong-Hon Kang & Takeshi Matsui & Masaru Enomoto & Hiroki Ikeda & T, 2022. "Serum miR-192-5p levels predict the efficacy of pegylated interferon therapy for chronic hepatitis B," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0263844
    DOI: 10.1371/journal.pone.0263844
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