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Longitudinal increase in albumin–bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis

Author

Listed:
  • Akira Sakamaki
  • Masaaki Takamura
  • Norihiro Sakai
  • Yusuke Watanabe
  • Yoshihisa Arao
  • Naruhiro Kimura
  • Toru Setsu
  • Hiroyuki Abe
  • Takeshi Yokoo
  • Hiroteru Kamimura
  • Shunsuke Tsubata
  • Nobuo Waguri
  • Toru Ishikawa
  • Hirokazu Kawai
  • Soichi Sugitani
  • Tomomi Sato
  • Kazuhiro Funakoshi
  • Masashi Watanabe
  • Kentarou Igarashi
  • Kenya Kamimura
  • Atsunori Tsuchiya
  • Yutaka Aoyagi
  • Shuji Terai

Abstract

Due to the developments in the treatment for hepatitis, it is possible to prevent the progression of liver fibrosis and improve patients’ prognosis even if it has already led to liver cirrhosis (LC). Consequently, a two-step study was conducted. To begin with, a retrospective study was conducted to identify the potential predictors of non-malignancy-related mortality from LC. Then, we prospectively analyzed the validity of these parameters as well as their association with patients’ quality of life. In the retrospective study, 89 cases were included, and the multivariate Cox regression analysis indicated that age (P = 0.012), model for end-stage liver disease (MELD) score (P = 0.012), and annual rate of change of the albumin–bilirubin (ALBI) score (P

Suggested Citation

  • Akira Sakamaki & Masaaki Takamura & Norihiro Sakai & Yusuke Watanabe & Yoshihisa Arao & Naruhiro Kimura & Toru Setsu & Hiroyuki Abe & Takeshi Yokoo & Hiroteru Kamimura & Shunsuke Tsubata & Nobuo Wagur, 2022. "Longitudinal increase in albumin–bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0263464
    DOI: 10.1371/journal.pone.0263464
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