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Prognostic value of cardiac magnetic resonance in patients with aortic stenosis: A systematic review and meta-analysis

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  • Chuan Zhang
  • Jie Liu
  • Shu Qin

Abstract

Background: The timing of surgery for aortic stenosis (AS) is imperfect, and the management of moderate AS and asymptomatic severe AS is still challenging. Myocardial fibrosis (MF) is the main pathological basis of cardiac decompensation in patients with AS and can be detected by cardiovascular magnetic resonance (CMR). The aim of this study was to evaluate the prognostic value of MF measured by CMR in patients with AS, which can provide a reference for the timing of aortic valve replacement (AVR). Methods: We searched Medline, Embase, and Web of Science to include all studies that investigated the prognostic value of CMR in patients with AS. The search deadline is March 31, 2021. The pooled relative risk (RR) or hazard ratio (HR) and 95% confidence intervals (CI) of the biomarkers including late gadolinium enhancement (LGE), Native T1 or extracellular volume (ECV) were calculated to evaluate the prognostic value. Results: 13 studies and 2,430 patients with AS were included in this study, the mean or medium follow-up duration for each study was ranged from 6 to 67.2 months. Meta-analysis showed the presence of LGE was associated with an increased risk for all-cause mortality (pooled RR: 2.14, 95% CI: 1.67–2.74, P

Suggested Citation

  • Chuan Zhang & Jie Liu & Shu Qin, 2022. "Prognostic value of cardiac magnetic resonance in patients with aortic stenosis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0263378
    DOI: 10.1371/journal.pone.0263378
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