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SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes

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  • Judit Hodrea
  • Adar Saeed
  • Agnes Molnar
  • Attila Fintha
  • Adrienn Barczi
  • Laszlo J Wagner
  • Attila J Szabo
  • Andrea Fekete
  • Dora B Balogh

Abstract

Introduction: Cardiovascular disease (CVD) is two to five times more prevalent in diabetic patients and is the leading cause of death. Therefore, identification of novel therapeutic strategies that reduce the risk of CVD is a research priority. Clinical trials showed that reduction in the relative risk of heart failure by sodium-glucose cotransporter 2 inhibitors (SGLT2i) are partly beyond their glucose lowering effects, however, the molecular mechanisms are still elusive. Here we investigated the role of SGLT2i dapagliflozin (DAPA) in the prevention of diabetes-induced cardiovascular complications. Methods: Type 1 diabetes was induced with streptozotocin (65 mg/bwkg, ip.) in adult, male Wistar rats. Following the onset of diabetes rats were treated for six weeks with DAPA (1 mg/bwkg/day, po.). Results: DAPA decreased blood glucose levels (D: 37±2.7 vs. D+DAPA: 18±5.6 mmol/L; p

Suggested Citation

  • Judit Hodrea & Adar Saeed & Agnes Molnar & Attila Fintha & Adrienn Barczi & Laszlo J Wagner & Attila J Szabo & Andrea Fekete & Dora B Balogh, 2022. "SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    • Handle: RePEc:plo:pone00:0263285
    DOI: 10.1371/journal.pone.0263285
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