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Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis

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  • Haoyu Wang
  • Ruiyuan Yang
  • Jing Jin
  • Zhoufeng Wang
  • Weimin Li

Abstract

Background: Current studies showed that idiopathic pulmonary fibrosis (IPF) may lead to a poor prognosis of lung cancer. We conducted a meta-analysis to explore the impact of concomitant IPF in lung cancer and its prognostic value. Methods: We searched the databases of PubMed, Web of Science, Embase up to Feb 10th, 2021 for relevant researches and merged the hazard ratios (HRs) and 95% confidence intervals (CIs) to evaluate the association between concomitant IPF and overall survival (OS) in patients with lung cancer. Results: Twelve studies involving 58424 patients were included in our meta-analysis. The results indicated that concomitant IPF was correlated with poor prognosis of lung cancer patients (HR = 1.99, 95%CI, 1.59–2.51). The association remained consistent after subgroup analysis and meta-regression stratified by study region, sample size, tumor histology, and therapy. In addition, our results were robust even after sensitivity analysis. Conclusions: Concomitant IPF may be a prognostic factor of lung cancer, which can lead to poor survival. However, further studies were necessary for evidence in clinical application.

Suggested Citation

  • Haoyu Wang & Ruiyuan Yang & Jing Jin & Zhoufeng Wang & Weimin Li, 2021. "Impact of concomitant idiopathic pulmonary fibrosis on prognosis in lung cancer patients: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0259784
    DOI: 10.1371/journal.pone.0259784
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