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Contribution of “complete response to treatment” to survival in patients with unresectable metastatic colorectal cancer: A retrospective analysis

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  • Gulcan Bulut
  • Merve Guner Oytun
  • Elvina Almuradova
  • Mustafa Harman
  • Ruchan Uslu
  • Bulent Karabulut

Abstract

Background: The aim of the study is to reveal the contribution of complete response (CR) to treatment to overall survival (OS) in patients with unresectable metastatic colorectal cancer. In addition, to evaluate progression-free survival (PFS) in patients who attained CR to treatment and to examine the clinicopathologic features of the patient group with CR. Methods: This article is a retrospective chart review. Patients diagnosed with metastatic colorectal cancer were divided into two groups. The systemic treatment was compared with the patients who received a full response according to the Response Evaluation Criteria in Solid Tumors (RECIST1.1) and those who did not attain CR (progression partial response and stable response) in terms of both PFS and OS data, and the effect of attaining CR to treatment on prognosis was evaluated. Results: A total of 222 patients were included in the study. 202 of 222 patients could be evaluated in terms of complete response. All data from their files were tabulated and analyzed retrospectively. The mean age of diagnosis of the study group was 60.13 ± 12.52 years. The total number of patients who attained CR to treatment was 31 (15.3%); 171 (84.6%) patients did not attain CR. Patients who had a CR had longer median PFS times than patients who did not have a CR (15.2 vs. 7.4 months, P

Suggested Citation

  • Gulcan Bulut & Merve Guner Oytun & Elvina Almuradova & Mustafa Harman & Ruchan Uslu & Bulent Karabulut, 2021. "Contribution of “complete response to treatment” to survival in patients with unresectable metastatic colorectal cancer: A retrospective analysis," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0259622
    DOI: 10.1371/journal.pone.0259622
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