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BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults

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  • Yuji Uchiyama
  • Hiroyuki Sakai
  • Takafumi Ando
  • Atsumichi Tachibana
  • Norihiro Sadato

Abstract

Many older adults have difficulty seeing brief visual stimuli which younger adults can easily recognize. The primary visual cortex (V1) may induce this difficulty. However, in neuroimaging studies, the V1 response change to the increase of temporal frequency of visual stimulus in older adults was unclear. Here we investigated the association between the temporal frequency of flickering stimuli and the BOLD activity within V1 in older adults, using surface-based fMRI analysis. The fMRI data from 29 healthy older participants stimulated by contrast-reversing checkerboard at temporal flicker frequencies of 2, 4, and 8 Hz were obtained. The participants also performed a useful field of view (UFOV) test. The slope coefficient of BOLD activity regarding the temporal frequency of the visual stimulus averaged within V1 regions of interest was positive and significantly different from zero. Group analysis in the V1 showed significant clusters with positive slope and no significant clusters with a negative slope. The correlation coefficient between the slope coefficient and UFOV performance was not significant. The results indicated that V1 BOLD response to a flickering visual stimulus increases as the stimulus temporal frequency increases from 2 to 8 Hz in older adults.

Suggested Citation

  • Yuji Uchiyama & Hiroyuki Sakai & Takafumi Ando & Atsumichi Tachibana & Norihiro Sadato, 2021. "BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-18, November.
    • Handle: RePEc:plo:pone00:0259243
    DOI: 10.1371/journal.pone.0259243
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    1. David Bressler & Nicole Spotswood & David Whitney, 2007. "Negative BOLD fMRI Response in the Visual Cortex Carries Precise Stimulus-Specific Information," PLOS ONE, Public Library of Science, vol. 2(5), pages 1-10, May.
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