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Toe pressure and toe brachial index are predictive of cardiovascular mortality regardless of the most diseased arterial segment in symptomatic lower-extremity artery disease—A retrospective cohort study

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  • V Koivunen
  • M Juonala
  • M Venermo
  • M Laivuori
  • J M Jalkanen
  • H H Hakovirta

Abstract

Objective: Although lower extremity arterial disease (LEAD) is most often multisegmental, the predominant disease location and risk factors differ between patients. Ankle-brachial index (ABI), toe-brachial index (TBI), and toe pressure (TP) are predictive of outcome in LEAD patients. Previously, we reported a classification method defining the most diseased arterial segment (MDAS); crural (CR), femoropopliteal (FP), or aortoiliac (AOI). Current study aimed to analyze the associations between MDAS, peripheral pressure measurements and cardiovascular mortality. Materials and methods: We reviewed retrospectively 729 consecutive LEAD patients (Rutherford 2–6) who underwent digital subtraction angiography between January, 2009 to August, 2011 and had standardized peripheral pressure measurements. Results: In Cox Regression analyses, cardiovascular mortality was associated with MDAS and non-invasive pressure indices as follows; MDAS AOI, TP

Suggested Citation

  • V Koivunen & M Juonala & M Venermo & M Laivuori & J M Jalkanen & H H Hakovirta, 2021. "Toe pressure and toe brachial index are predictive of cardiovascular mortality regardless of the most diseased arterial segment in symptomatic lower-extremity artery disease—A retrospective cohort stu," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0259122
    DOI: 10.1371/journal.pone.0259122
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