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Potential biomarkers of major depression diagnosis and chronicity

Author

Listed:
  • Ana Cecília de Menezes Galvão
  • Raíssa Nobrega Almeida
  • Geovan Menezes de Sousa Júnior
  • Mário André Leocadio-Miguel
  • Fernanda Palhano-Fontes
  • Dráulio Barros de Araujo
  • Bruno Lobão-Soares
  • João Paulo Maia-de-Oliveira
  • Emerson Arcoverde Nunes
  • Jaime Eduardo Cecilio Hallak
  • Jerome Sarris
  • Nicole Leite Galvão-Coelho

Abstract

Background: Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. Methods: We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve. Results: For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p

Suggested Citation

  • Ana Cecília de Menezes Galvão & Raíssa Nobrega Almeida & Geovan Menezes de Sousa Júnior & Mário André Leocadio-Miguel & Fernanda Palhano-Fontes & Dráulio Barros de Araujo & Bruno Lobão-Soares & João P, 2021. "Potential biomarkers of major depression diagnosis and chronicity," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-17, September.
    • Handle: RePEc:plo:pone00:0257251
    DOI: 10.1371/journal.pone.0257251
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