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Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis

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  • Jia-yue Xia
  • Chao Yang
  • Deng-feng Xu
  • Hui Xia
  • Li-gang Yang
  • Gui-ju Sun

Abstract

The efficacy of cranberry (Vaccinium spp.) as adjuvant therapy in preventing urinary tract infections (UTIs) remains controversial. This study aims to update and determine cranberry effects as adjuvant therapy on the recurrence rate of UTIs in susceptible groups. According to PRISMA guidelines, we conducted a literature search in Web of Science, PubMed, Embase, Scopus, and the Cochrane Library from their inception dates to June 2021. We included articles with data on the incidence of UTIs in susceptible populations using cranberry-containing products. We then conducted a trial sequential analysis to control the risk of type I and type II errors. This meta-analysis included 23 trials with 3979 participants. We found that cranberry-based products intake can significantly reduce the incidence of UTIs in susceptible populations (risk ratio (RR) = 0.70; 95% confidence interval(CI): 0.59 ~ 0.83; P

Suggested Citation

  • Jia-yue Xia & Chao Yang & Deng-feng Xu & Hui Xia & Li-gang Yang & Gui-ju Sun, 2021. "Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-17, September.
    • Handle: RePEc:plo:pone00:0256992
    DOI: 10.1371/journal.pone.0256992
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