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Food insecurity, drug resistance and non-disclosure are associated with virologic non-suppression among HIV pregnant women on antiretroviral treatment

Author

Listed:
  • Bhavna H Chohan
  • Keshet Ronen
  • Brian Khasimwa
  • Daniel Matemo
  • Lusi Osborn
  • Jennifer A Unger
  • Alison L Drake
  • Ingrid A Beck
  • Lisa M Frenkel
  • John Kinuthia
  • Grace John-Stewart

Abstract

We determined social and behavioral factors associated with virologic non-suppression among pregnant women receiving Option B+ antiretroviral treatment (ART). Baseline data was used from women in Mobile WAChX trial from 6 public maternal child health (MCH) clinics in Kenya. Virologic non-suppression was defined as HIV viral load (VL) ≥1000 copies/ml. Antiretroviral resistance testing was performed using oligonucleotide ligation (OLA) assay. ART adherence information, motivation and behavioral skills were assessed using Lifewindows IMB tool, depression using PHQ-9, and food insecurity with the Household Food Insecurity Access Scale. Correlates of virologic non-suppression were assessed using Poisson regression. Among 470 pregnant women on ART ≥4 months, 57 (12.1%) had virologic non-suppression, of whom 65% had HIV drug resistance mutations. In univariate analyses, risk of virologic non-suppression was associated with moderate-to-severe food insecurity (RR 1.80 [95% CI 1.06–3.05]), and varied significantly by clinic site (range 2%-22%, p

Suggested Citation

  • Bhavna H Chohan & Keshet Ronen & Brian Khasimwa & Daniel Matemo & Lusi Osborn & Jennifer A Unger & Alison L Drake & Ingrid A Beck & Lisa M Frenkel & John Kinuthia & Grace John-Stewart, 2021. "Food insecurity, drug resistance and non-disclosure are associated with virologic non-suppression among HIV pregnant women on antiretroviral treatment," PLOS ONE, Public Library of Science, vol. 16(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0256249
    DOI: 10.1371/journal.pone.0256249
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