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Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis

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  • Hui Jiang
  • Xiujuan Gu
  • Zhihua Zuo
  • Gang Tian
  • Jinbo Liu

Abstract

Background: Circulating tumor cells (CTCs) have been considered diagnostic and prognostic biomarkers for urothelial cancer. However, the prognostic role of CTCs in bladder cancer (BC) remains controversial. Here, we conducted a meta-analysis to evaluate the prognostic significance of CTCs for patients with BC. Methods: All studies relevant to this topic were searched in the PubMed, Embase, and Web of Science databases. The hazard ratio (HR) and 95% confidence interval (95% CI) were set as effect measures. The outcomes were overall survival (OS), cancer-free survival (CSS), progression-free survival (PFS)/time to progression (TTP), and disease-free survival (DFS)/recurrence-free survival (RFS)/time to first recurrence (TFR). All analyses were conducted in STATA 15.1. Results: Eleven eligible studies comprising 1,062 patients with BC were included in this meta-analysis. Overall analyses showed that CTC-positive patients had poorer survival (OS: HR 3.88, 95% CI 2.52–5.96, p

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  • Hui Jiang & Xiujuan Gu & Zhihua Zuo & Gang Tian & Jinbo Liu, 2021. "Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0254433
    DOI: 10.1371/journal.pone.0254433
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    1. Chris Berdik, 2017. "Unlocking bladder cancer," Nature, Nature, vol. 551(7679), pages 34-35, November.
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