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Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer

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Listed:
  • Han-Gil Kim
  • Seung Yoon Yang
  • Yoon Dae Han
  • Min Soo Cho
  • Byung Soh Min
  • Kang Young Lee
  • Nam Kyu Kim
  • Hyuk Hur

Abstract

Background: The purpose is to investigate prognosis according to serum CEA levels before and after surgery in patients with stage IIA colon cancer who do not show high-risk features. Methods: Among the patients diagnosed with colon adenocarcinoma between April 2011 and December 2017, 462 patients were confirmed as low-risk stage IIA after surgery and enrolled. The ROC curve was used to determine cut-off values of pre- and postoperative CEA. Patients were classified into three groups using these new cut-off values. Results: All recurrence occurred in 52 of 463 patients (11.2%). However, recurrence in group H was 15.9%, which was slightly higher than the other two groups (P = 0.04). Group L and M showed 10.5% and 12.8% overall survival, group H was higher at 21.0% (P = 0.005). Recurrence was the only risk factor in group H was significantly higher in group L (HR 2.008, 95% CI, 1.123–3.589, P = 0.019). Mortality was similar to recurrence (HR 1.975, 95% CI 1.091–3.523, P = 0.044). Conclusion: Among patients with low-risk stage IIA colon cancer, recurrence and mortality rates were higher when perioperative serum CEA levels were above a certain level. Therefore, high CEA level should be considered a high-risk feature and adjuvant chemotherapy should be performed.

Suggested Citation

  • Han-Gil Kim & Seung Yoon Yang & Yoon Dae Han & Min Soo Cho & Byung Soh Min & Kang Young Lee & Nam Kyu Kim & Hyuk Hur, 2021. "Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0252566
    DOI: 10.1371/journal.pone.0252566
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