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Efficacy and cost of high-frequency IGRT in elderly stage III non-small-cell lung cancer patients

Author

Listed:
  • Samuel P Heilbroner
  • Eric P Xanthopoulos
  • Donna Buono
  • Daniel Carrier
  • Ben Y Durkee
  • Michael Corradetti
  • Tony J C Wang
  • Alfred I Neugut
  • Dawn L Hershman
  • Simon K Cheng

Abstract

Background: High-frequency image-guided radiotherapy (hfIGRT) is ubiquitous but its benefits are unproven. We examined the cost effectiveness of hfIGRT in stage III non-small-cell lung cancer (NSCLC). Methods: We selected stage III NSCLC patients ≥66 years old who received definitive radiation therapy from the Surveillance, Epidemiology, and End-Results-Medicare database. Patients were stratified by use of hfIGRT using Medicare claims. Predictors for hfIGRT were calculated using a logistic model. The impact of hfIGRT on lung toxicity free survival (LTFS), esophageal toxicity free survival (ETFS), cancer-specific survival (CSS), overall survival (OS), and cost of treatment was calculated using Cox regressions, propensity score matching, and bootstrap methods. Results: Of the 4,430 patients in our cohort, 963 (22%) received hfIGRT and 3,468 (78%) did not. By 2011, 49% of patients were receiving hfIGRT. Predictors of hfIGRT use included treatment with intensity-modulated radiotherapy (IMRT) (OR = 7.5, p

Suggested Citation

  • Samuel P Heilbroner & Eric P Xanthopoulos & Donna Buono & Daniel Carrier & Ben Y Durkee & Michael Corradetti & Tony J C Wang & Alfred I Neugut & Dawn L Hershman & Simon K Cheng, 2021. "Efficacy and cost of high-frequency IGRT in elderly stage III non-small-cell lung cancer patients," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0252053
    DOI: 10.1371/journal.pone.0252053
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