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Cluster analysis of men undergoing surgery for BPH/LUTS reveals prominent roles of both bladder outlet obstruction and diminished bladder contractility

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  • Andrew J Schneider
  • Matthew Grimes
  • Will Lyon
  • Amanda Kemper
  • Sijian Wang
  • Wade Bushman

Abstract

Lower urinary tract symptoms (LUTS) in aging men are commonly attributed to bladder outlet obstruction from benign prostatic hyperplasia (BPH) but BPH/LUTS often reflects a confluence of many factors. We performed a hierarchical cluster analysis using four objective patient characteristics (age, HTN, DM, and BMI), and five pre-operative urodynamic variables (volume at first uninhibited detrusor contraction, number of uninhibited contractions, Bladder Outlet Obstruction Index (BOOI), Bladder Contractility Index (BCI) and Bladder Power at Qmax) to identify meaningful subgroups within a cohort of 94 men undergoing surgery for BPH/LUTS. Two meaningful subgroups (clusters) were identified. Significant differences between the two clusters included Prostate Volume (95 vs 53 cc; p-value = 0.001), BOOI (mean 70 vs 49; p-value = 0.001), BCI (mean 129 vs 83; p-value

Suggested Citation

  • Andrew J Schneider & Matthew Grimes & Will Lyon & Amanda Kemper & Sijian Wang & Wade Bushman, 2021. "Cluster analysis of men undergoing surgery for BPH/LUTS reveals prominent roles of both bladder outlet obstruction and diminished bladder contractility," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0251721
    DOI: 10.1371/journal.pone.0251721
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