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Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis

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  • Widi Atmoko
  • Putu Angga Risky Raharja
  • Ponco Birowo
  • Agus Rizal Ardy Hariandy Hamid
  • Akmal Taher
  • Nur Rasyid

Abstract

Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P

Suggested Citation

  • Widi Atmoko & Putu Angga Risky Raharja & Ponco Birowo & Agus Rizal Ardy Hariandy Hamid & Akmal Taher & Nur Rasyid, 2021. "Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-18, May.
    • Handle: RePEc:plo:pone00:0251235
    DOI: 10.1371/journal.pone.0251235
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