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Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution

Author

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  • Diedert L De Paep
  • Freya Van Hulle
  • Zhidong Ling
  • Marian Vanhoeij
  • Jacques Pirenne
  • Bart Keymeulen
  • Daniel Pipeleers
  • Daniel Jacobs-Tulleneers-Thevissen

Abstract

Organs from donors after controlled circulatory death (DCD III) exhibit a higher risk for graft dysfunction due to an initial period of warm ischemia. This procurement condition can also affect the yield of beta cells in islet isolates from donor pancreases, and hence their use for transplantation. The present study uses data collected and generated by our Beta Cell Bank to compare the number of beta cells in isolates from DCD III (n = 141) with that from donors after brain death (DBD, n = 609), before and after culture, and examines the influence of donor and procurement variables. Beta cell number per DCD III-organ was significantly lower (58 x 106 versus 84 x 106 beta cells per DBD-organ; p

Suggested Citation

  • Diedert L De Paep & Freya Van Hulle & Zhidong Ling & Marian Vanhoeij & Jacques Pirenne & Bart Keymeulen & Daniel Pipeleers & Daniel Jacobs-Tulleneers-Thevissen, 2021. "Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0251055
    DOI: 10.1371/journal.pone.0251055
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