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Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis

Author

Listed:
  • Hidekatsu Kuroda
  • Yudai Fujiwara
  • Tamami Abe
  • Tomoaki Nagasawa
  • Takuma Oguri
  • Sachiyo Noguchi
  • Naohisa Kamiyama
  • Yasuhiro Takikawa

Abstract

Background and aims: We investigated the usefulness of combining two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter for assessing the risk of progressive non-alcoholic steatohepatitis, defined as non-alcoholic steatohepatitis with a non-alcoholic fatty liver disease activity score of ≥4 and a fibrosis stage of ≥2. Methods: This prospective study included 202 patients with non-alcoholic fatty liver disease who underwent two-dimensional shear wave elastography, ultrasound-guided attenuation parameter, vibration-controlled transient elastography, the controlled attenuation parameter, and liver biopsy on the same day. Patients were grouped according to liver stiffness measurement using two-dimensional shear wave elastography and the attenuation coefficient, assessed using the ultrasound-guided attenuation parameter: A, low liver stiffness measurement/low attenuation coefficient; B, low liver stiffness measurement/high attenuation coefficient; C, high liver stiffness measurement/low attenuation coefficient; and D, high liver stiffness measurement/high attenuation coefficient. Results: Two-dimensional shear wave elastography and vibration-controlled transient elastography had equivalent diagnostic performance for fibrosis. The areas under the curve of the ultrasound-guided attenuation parameter for identifying steatosis grades ≥S1, ≥S2, and S3 were 0.89, 0.91, and 0.92, respectively, which were significantly better than those of the controlled attenuation parameter (P

Suggested Citation

  • Hidekatsu Kuroda & Yudai Fujiwara & Tamami Abe & Tomoaki Nagasawa & Takuma Oguri & Sachiyo Noguchi & Naohisa Kamiyama & Yasuhiro Takikawa, 2021. "Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0249493
    DOI: 10.1371/journal.pone.0249493
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