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Risk factors for delirium among hospitalized patients in Zambia

Author

Listed:
  • Justin K Banerdt
  • Kondwelani Mateyo
  • Yan Yan
  • Dandan Liu
  • Yi Zuo
  • Chiara Di Gravio
  • Julia C Thome
  • Elisabeth D Riviello
  • Deanna Saylor
  • E Wesley Ely
  • Douglas C Heimburger

Abstract

Objective: To identify risk factors for delirium among hospitalized patients in Zambia. Methods: We conducted a prospective cohort study at the University Teaching Hospital in Lusaka, Zambia, from October 2017 to April 2018. We report associations of exposures including sociodemographic and clinical factors with delirium over the first three days of hospital admission, assessed using a modified Brief Confusion Assessment Method (bCAM). Findings: 749 patients were included for analysis (mean age, 42.9 years; 64.8% men; 47.3% with HIV). In individual regression analyses of potential delirium risk factors adjusted for age, sex and education, factors significantly associated with delirium included being divorced/widowed (OR 1.64, 95% CI 1.09–2.47), lowest tercile income (OR 1.58, 95% CI 1.04–2.40), informal employment (OR 1.97, 95% CI 1.25–3.15), untreated HIV infection (OR 2.18, 95% CI 1.21–4.06), unknown HIV status (OR 2.90, 95% CI 1.47–6.16), history of stroke (OR 2.70, 95% CI 1.15–7.19), depression/anxiety (OR 1.52, 95% CI 1.08–2.14), alcohol overuse (OR 1.96, 95% CI 1.39–2.79), sedatives ordered on admission (OR 3.77, 95% CI 1.70–9.54), severity of illness (OR 2.00, 95% CI 1.82–2.22), neurological (OR 7.66, 95% CI 4.90–12.24) and pulmonary-system admission diagnoses (OR 1.91, 95% CI 1.29–2.85), and sepsis (OR 2.44, 95% CI 1.51–4.08). After combining significant risk factors into a multivariable regression analysis, severity of illness, history of stroke, and being divorced/widowed remained predictive of delirium (p

Suggested Citation

  • Justin K Banerdt & Kondwelani Mateyo & Yan Yan & Dandan Liu & Yi Zuo & Chiara Di Gravio & Julia C Thome & Elisabeth D Riviello & Deanna Saylor & E Wesley Ely & Douglas C Heimburger, 2021. "Risk factors for delirium among hospitalized patients in Zambia," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0249097
    DOI: 10.1371/journal.pone.0249097
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    References listed on IDEAS

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    1. Tim Baker & Carl Otto Schell & Edwin Lugazia & Jonas Blixt & Moses Mulungu & Markus Castegren & Jaran Eriksen & David Konrad, 2015. "Vital Signs Directed Therapy: Improving Care in an Intensive Care Unit in a Low-Income Country," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-15, December.
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