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Impact of adenosine on mechanisms sustaining persistent atrial fibrillation: Analysis of contact electrograms and non-invasive ECGI mapping data

Author

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  • Gurpreet Singh Dhillon
  • Nikhil Ahluwalia
  • Shohreh Honarbakhsh
  • Adam Graham
  • Antonio Creta
  • Hakam Abbass
  • Anthony Chow
  • Mark J Earley
  • Pier D Lambiase
  • Richard J Schilling
  • Ross J Hunter

Abstract

Background: We evaluated the effect of adenosine upon mechanisms sustaining persistent AF through analysis of contact electrograms and ECGI mapping. Methods: Persistent AF patients undergoing catheter ablation were included. ECGI maps and cycle length (CL) measurements were recorded in the left and right atrial appendages and repeated following boluses of 18 mg of intravenous adenosine. Potential drivers (PDs) were defined as focal or rotational activations completing ≥ 1.5 revolutions. Distribution of PDs was assessed using an 18 segment biatrial model. Results: 46 patients were enrolled. Mean age was 63.4 ± 9.8 years with 33 (72%) being male. There was no significant difference in the number of PDs recorded at baseline compared to adenosine (42.1 ± 15.2 vs 40.4 ± 13.0; p = 0.417), nor in the number of segments harbouring PDs, (13 (11–14) vs 12 (10–14); p = 0.169). There was a significantly higher percentage of PDs that were focal in the adenosine maps (36.2 ± 15.2 vs 32.2 ± 14.4; p

Suggested Citation

  • Gurpreet Singh Dhillon & Nikhil Ahluwalia & Shohreh Honarbakhsh & Adam Graham & Antonio Creta & Hakam Abbass & Anthony Chow & Mark J Earley & Pier D Lambiase & Richard J Schilling & Ross J Hunter, 2021. "Impact of adenosine on mechanisms sustaining persistent atrial fibrillation: Analysis of contact electrograms and non-invasive ECGI mapping data," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0248951
    DOI: 10.1371/journal.pone.0248951
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