Author
Listed:
- Lili Zhao
- Jing Bao
- Ying Shang
- Ying Zhang
- Lu Yin
- Yan Yu
- Yu Xie
- Li Chen
- Yali Zheng
- Yu Xu
- Zhancheng Gao
Abstract
Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731–0.912), 0.847 (95% CI 0.755–0.938), and 0.847 (95% CI 0.738–0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy.
Suggested Citation
Lili Zhao & Jing Bao & Ying Shang & Ying Zhang & Lu Yin & Yan Yu & Yu Xie & Li Chen & Yali Zheng & Yu Xu & Zhancheng Gao, 2021.
"The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study,"
PLOS ONE, Public Library of Science, vol. 16(3), pages 1-12, March.
Handle:
RePEc:plo:pone00:0248002
DOI: 10.1371/journal.pone.0248002
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