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Combined pre- and post-capillary pulmonary hypertension: The clinical implications for patients with heart failure

Author

Listed:
  • Tatsuro Ibe
  • Hiroshi Wada
  • Kenichi Sakakura
  • Yusuke Ugata
  • Hisataka Maki
  • Kei Yamamoto
  • Masaru Seguchi
  • Yousuke Taniguchi
  • Hiroyuki Jinnouchi
  • Shin-ichi Momomura
  • Hideo Fujita

Abstract

Background: The prognostic implications of combined pre- and post-capillary pulmonary hypertension (Cpc-PH) in patients with pulmonary hypertension due to left heart disease (PH-LHD) remain controversial. The aim of this retrospective study was to evaluate the new PH-LHD criteria, recommended by the 6th World Symposium on Pulmonary Hypertension and to determine the prognostic value of Cpc-PH. Methods: A total of 701 patients with symptomatic heart failure who had undergone right-heart catheterization were divided into the following four groups: (i) Isolated post-capillary PH (Ipc-PH) group; mean pulmonary artery pressure (mPAP) >20 mmHg, pulmonary artery wedge pressure (PAWP) >15 mmHg, and pulmonary vascular resistance (PVR) 20 mmHg, PAWP >15 mmHg, and PVR ≥3 WU (iii) borderline-PH group; mPAP >20 mmHg and PAWP ≤15 mmHg (iv) non-PH group; mPAP ≤20 mmHg. Multivariate Cox hazard analysis was used to investigate whether Cpc-PH was associated with cardiac outcomes. Results: The study subjects were allocated into the Ipc-PH (n = 268), Cpc-PH (n = 54), borderline-PH (n = 112), or non-PH (n = 267) groups. The Cpc-PH group was associated significantly with adverse cardiac events even after adjustment for clinically relevant confounding factors for heart failure prognosis (vs. non-PH group: HR 2.98 [95% CI 1.81–4.90], P

Suggested Citation

  • Tatsuro Ibe & Hiroshi Wada & Kenichi Sakakura & Yusuke Ugata & Hisataka Maki & Kei Yamamoto & Masaru Seguchi & Yousuke Taniguchi & Hiroyuki Jinnouchi & Shin-ichi Momomura & Hideo Fujita, 2021. "Combined pre- and post-capillary pulmonary hypertension: The clinical implications for patients with heart failure," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0247987
    DOI: 10.1371/journal.pone.0247987
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