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Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

Author

Listed:
  • Jingjing He
  • Desheng Kong
  • Zhifen Yang
  • Ruiyun Guo
  • Asiamah Ernest Amponsah
  • Baofeng Feng
  • Xiaolin Zhang
  • Wei Zhang
  • Aijing Liu
  • Jun Ma
  • Timothy O’Brien
  • Huixian Cui

Abstract

Background: Diabetes mellitus as a chronic metabolic disease is threatening human health seriously. Although numerous clinical trials have been registered for the treatment of diabetes with stem cells, no articles have been published to summarize the efficacy and safety of mesenchymal stem cells (MSCs) in randomized controlled trials (RCTs). Methods and findings: The aim of this study was to systematically review the evidence from RCTs and, where possible, conduct meta-analyses to provide a reliable numerical summary and the most comprehensive assessment of therapeutic efficacy and safety with MSCs in diabetes. PubMed, Web of Science, Ovid, the Cochrane Library and CNKI were searched. The retrieval time was from establishment of these databases to January 4, 2020. Seven RCTs were eligible for analysis, including 413 participants. Meta-analysis results showed that there were no significant differences in the reduction of fasting plasma glucose (FPG) compared to the baseline [mean difference (MD) = -1.05, 95% confidence interval (CI) (-2.26,0.16), P

Suggested Citation

  • Jingjing He & Desheng Kong & Zhifen Yang & Ruiyun Guo & Asiamah Ernest Amponsah & Baofeng Feng & Xiaolin Zhang & Wei Zhang & Aijing Liu & Jun Ma & Timothy O’Brien & Huixian Cui, 2021. "Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-15, March.
    • Handle: RePEc:plo:pone00:0247662
    DOI: 10.1371/journal.pone.0247662
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