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Amyotrophic Lateral Sclerosis (ALS) prediction model derived from plasma and CSF biomarkers

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  • Radhika Khosla
  • Manjari Rain
  • Suresh Sharma
  • Akshay Anand

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder of motor neurons which leads to complete loss of movement in patients. The only FDA approved drug Riluzole provides only symptomatic relief to patients. Early Diagnosis of the disease warrants the importance of diagnostic and prognostic models for predicting disease and disease progression respectively. In the present study we represent the predictive statistical model for ALS using plasma and CSF biomarkers. Forward stepwise (Binary likelihood) Logistic regression model is developed for prediction of ALS. The model has been shown to have excellent validity (94%) with good sensitivity (98%) and specificity (93%). The area under the ROC curve is 99.3%. Along with age and BMI, VEGF (Vascular Endothelial Growth Factor), VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) and TDP43 (TAR DNA Binding Protein 43) in CSF and VEGFR2 and OPTN (Optineurin) in plasma are good predictors of ALS.

Suggested Citation

  • Radhika Khosla & Manjari Rain & Suresh Sharma & Akshay Anand, 2021. "Amyotrophic Lateral Sclerosis (ALS) prediction model derived from plasma and CSF biomarkers," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0247025
    DOI: 10.1371/journal.pone.0247025
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    References listed on IDEAS

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    1. Mei-Lyn Ong & Pei Fang Tan & Joanna D Holbrook, 2017. "Predicting functional decline and survival in amyotrophic lateral sclerosis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-16, April.
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