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A review of methods for addressing components of interventions in meta-analysis

Author

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  • Maria Petropoulou
  • Orestis Efthimiou
  • Gerta Rücker
  • Guido Schwarzer
  • Toshi A Furukawa
  • Alessandro Pompoli
  • Huiberdina L Koek
  • Cinzia Del Giovane
  • Nicolas Rodondi
  • Dimitris Mavridis

Abstract

Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.

Suggested Citation

  • Maria Petropoulou & Orestis Efthimiou & Gerta Rücker & Guido Schwarzer & Toshi A Furukawa & Alessandro Pompoli & Huiberdina L Koek & Cinzia Del Giovane & Nicolas Rodondi & Dimitris Mavridis, 2021. "A review of methods for addressing components of interventions in meta-analysis," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0246631
    DOI: 10.1371/journal.pone.0246631
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