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Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis

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  • Xiaohong Chen
  • Lifang Feng
  • Hui Yao
  • Luhong Yang
  • Yuan Qin

Abstract

Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration. This systemic review and meta-analysis aimed to investigate the efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia (HH). The meta-analysis of the efficacy and safety of diazoxide in treating HH was performed by searching relevant studies in the PubMed, Embase, and Cochrane databases. The findings were summarized, and the pooled effect size and its 95% confidence interval (CI) were calculated. A total of 6 cohort studies, involving 1142 participants, met the inclusion criteria. Among the cohort studies, the pooled estimate of the response rate of diazoxide therapy was 71% (95% CI 50%–93%, Pheterogeneity

Suggested Citation

  • Xiaohong Chen & Lifang Feng & Hui Yao & Luhong Yang & Yuan Qin, 2021. "Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0246463
    DOI: 10.1371/journal.pone.0246463
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