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Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism

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  • Ravindra Shukla
  • Mayank Ganeshani
  • Monica Agarwal
  • Rakesh Jangir
  • Gaurav Kandel
  • Shrimanjunath Sankanagoudar
  • Shival Srivastava

Abstract

Introduction: The presence of rheumatism is well recognized in primary hypothyroidism. Dehydroepiandrstenedione sulphate (DHEAS) is associated with rheumatological diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study aims to explore relationship between joint pains and DHEAS levels in primary hypothyroidism. Methods: Retrospective study of 78 subjects with subclinical hypothyroidism, with TSH within reference range. The joint pains were evaluated by European Union League against rheumatism (EULAR-CSA) score and compared with serum DHEAS, RA factor, Anti-TPO antibody, highly sensitive C-recative protein (hsCRP), vitamin D levels. Result: DHEAS levels

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  • Ravindra Shukla & Mayank Ganeshani & Monica Agarwal & Rakesh Jangir & Gaurav Kandel & Shrimanjunath Sankanagoudar & Shival Srivastava, 2021. "Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0246195
    DOI: 10.1371/journal.pone.0246195
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