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Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion

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Listed:
  • Fumihito Hikage
  • Masato Furuhashi
  • Yosuke Ida
  • Hiroshi Ohguro
  • Megumi Watanabe
  • Soma Suzuki
  • Kaku Itoh

Abstract

The main objective of current study was to identify the fatty acid-binding protein 4 (FABP4) expressed in both adipocytes and macrophages in vitreous fluid from patients with retinal vein occlusion (RVO). Patients with RVO (n = 14, CRVO; central RVO n = 5, BRVO; branch RVO n = 9) and non-RVO (macular hole or epiretinal membrane, n = 18) were surgically treated by a 25 or 27G vitrectomy. Undiluted vitreous fluid samples obtained as the result of surgery were subjected to enzyme-linked immunosorbent assays to measure the levels of FABP4 and vascular endothelial growth factor A (VEGFA).Data including ocular blood flow by laser speckle flow graphy (LSFG), height and weight, systemic blood pressures and several blood biochemistry values were collected. Among the LSFG mean blur rate (MBR) values of the optic nerve head (ONH) at baseline, MA (MBR of all area), MV (MBR of the vascular area), and MV-MT (MBR of the tissue area) were significantly decreased in patients with CRVO. The levels of V-FABP4 and V-VEGFA were relatively or significantly (P

Suggested Citation

  • Fumihito Hikage & Masato Furuhashi & Yosuke Ida & Hiroshi Ohguro & Megumi Watanabe & Soma Suzuki & Kaku Itoh, 2021. "Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0245763
    DOI: 10.1371/journal.pone.0245763
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