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Non-persistence with anti-platelet therapy and long-term mortality after ischemic stroke: A nationwide study

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  • Seung Jae Kim
  • Oh Deog Kwon
  • Ho Chun Choi
  • Eung-Joon Lee
  • BeLong Cho

Abstract

Background: We tried to investigate the effect of non-persistence with antiplatelets after ischemic stroke on long-term all-cause mortality (ACM). Methods and findings: We selected newly diagnosed ischemic stroke patients aged ≥20years who were newly treated with aspirin or clopidogrel from 2003–2010 Korean National Health Insurance Service-National Sample Cohort, a random sample of 2.2% of total population. Subjects were divided into two pairs of groups according to persistence with antiplatelets at 6 and 12 months: those who discontinued antiplatelets within 6 months (DA6M) and those who continued them for 6 or months or more (CA6M); and those who discontinued antiplatelets within 12 months (DA12M) and those who continued them for 12 months or more (CA12M). Those who died within 6 months among DA6M and those who died within 12 months among DA12M were excluded along with those with medication possession ratio

Suggested Citation

  • Seung Jae Kim & Oh Deog Kwon & Ho Chun Choi & Eung-Joon Lee & BeLong Cho, 2021. "Non-persistence with anti-platelet therapy and long-term mortality after ischemic stroke: A nationwide study," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0244718
    DOI: 10.1371/journal.pone.0244718
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