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C-reactive protein can predict dose intensity, time to treatment failure and overall survival in HCC treated with lenvatinib

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  • Tsuguru Hayashi
  • Michihiko Shibata
  • Shinji Oe
  • Koichiro Miyagawa
  • Yuichi Honma
  • Masaru Harada

Abstract

Background and aim: Lenvatinib has become a first line treatment for unresectable hepatocellular carcinoma (HCC). However, continued administration is impossible in many patients due to treatment resistance and severe adverse events. This study aimed to identify predicting factors to select patients likely to benefit from lenvatinib treatment. Methods: We retrospectively analyzed 53 patients who were treated with lenvatinib for unresectable HCC. They were divided to two groups; low C-reactive protein (CRP) group with pretreatment serum CRP level

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  • Tsuguru Hayashi & Michihiko Shibata & Shinji Oe & Koichiro Miyagawa & Yuichi Honma & Masaru Harada, 2020. "C-reactive protein can predict dose intensity, time to treatment failure and overall survival in HCC treated with lenvatinib," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0244370
    DOI: 10.1371/journal.pone.0244370
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