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A study of longitudinal mobile health data through fuzzy clustering methods for functional data: The case of allergic rhinoconjunctivitis in childhood

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  • Paolo Giordani
  • Serena Perna
  • Annamaria Bianchi
  • Antonio Pizzulli
  • Salvatore Tripodi
  • Paolo Maria Matricardi

Abstract

The use of mobile communication devices in health care is spreading worldwide. A huge amount of health data collected by these devices (mobile health data) is nowadays available. Mobile health data may allow for real-time monitoring of patients and delivering ad-hoc treatment recommendations. This paper aims at showing how this may be done by exploiting the potentialities of fuzzy clustering techniques. In fact, such techniques can be fruitfully applied to mobile health data in order to identify clusters of patients for diagnostic classification and cluster-specific therapies. However, since mobile health data are full of noise, fuzzy clustering methods cannot be directly applied to mobile health data. Such data must be denoised prior to analyzing them. When longitudinal mobile health data are available, functional data analysis represents a powerful tool for filtering out the noise in the data. Fuzzy clustering methods for functional data can then be used to determine groups of patients. In this work we develop a fuzzy clustering method, based on the concept of medoid, for functional data and we apply it to longitudinal mHealth data on daily symptoms and consumptions of anti-symptomatic drugs collected by two sets of patients in Berlin (Germany) and Ascoli Piceno (Italy) suffering from allergic rhinoconjunctivitis. The studies showed that clusters of patients with similar changes in symptoms were identified opening the possibility of precision medicine.

Suggested Citation

  • Paolo Giordani & Serena Perna & Annamaria Bianchi & Antonio Pizzulli & Salvatore Tripodi & Paolo Maria Matricardi, 2020. "A study of longitudinal mobile health data through fuzzy clustering methods for functional data: The case of allergic rhinoconjunctivitis in childhood," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-23, November.
    • Handle: RePEc:plo:pone00:0242197
    DOI: 10.1371/journal.pone.0242197
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    1. Julien Jacques & Cristian Preda, 2014. "Functional data clustering: a survey," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 8(3), pages 231-255, September.
    2. C. Abraham & P. A. Cornillon & E. Matzner‐Løber & N. Molinari, 2003. "Unsupervised Curve Clustering using B‐Splines," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 30(3), pages 581-595, September.
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    2. Ferraro, Maria Brigida, 2024. "Fuzzy k-Means: history and applications," Econometrics and Statistics, Elsevier, vol. 30(C), pages 110-123.

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