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Remote testing of vitamin D levels across the UK MS population—A case control study

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  • Nicola Vickaryous
  • Mark Jitlal
  • Benjamin Meir Jacobs
  • Rod Middleton
  • Siddharthan Chandran
  • Niall John James MacDougall
  • Gavin Giovannoni
  • Ruth Dobson

Abstract

Objective: The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK. Methods: People with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls. Results: 1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p

Suggested Citation

  • Nicola Vickaryous & Mark Jitlal & Benjamin Meir Jacobs & Rod Middleton & Siddharthan Chandran & Niall John James MacDougall & Gavin Giovannoni & Ruth Dobson, 2020. "Remote testing of vitamin D levels across the UK MS population—A case control study," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-13, December.
  • Handle: RePEc:plo:pone00:0241459
    DOI: 10.1371/journal.pone.0241459
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