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The inclusion of blastomeres into the inner cell mass in early-stage human embryos depends on the sequence of cell cleavages during the fourth division

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  • Junko Otsuki
  • Toshiroh Iwasaki
  • Noritoshi Enatsu
  • Yuya Katada
  • Kohyu Furuhashi
  • Masahide Shiotani

Abstract

The fate of the ICM in humans is still unknown, due to the ethical difficulties surrounding experimentation in this field. In this study we have explored the existing time-lapse recording data of embryos in the early stages of development, taking advantage of the large refractile bodies (RBs) within blastomeres as cellular markers. Our study found that the cellular composition of the ICM in humans is largely determined at the time of the fourth division and blastomeres which cleave first to fourth, during the fourth division from 8 cells to 16 cells, have the potential to be incorporated in the ICM.

Suggested Citation

  • Junko Otsuki & Toshiroh Iwasaki & Noritoshi Enatsu & Yuya Katada & Kohyu Furuhashi & Masahide Shiotani, 2020. "The inclusion of blastomeres into the inner cell mass in early-stage human embryos depends on the sequence of cell cleavages during the fourth division," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0240936
    DOI: 10.1371/journal.pone.0240936
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    1. Hui Yi Grace Lim & Yanina D. Alvarez & Maxime Gasnier & Yiming Wang & Piotr Tetlak & Stephanie Bissiere & Hongmei Wang & Maté Biro & Nicolas Plachta, 2020. "Keratins are asymmetrically inherited fate determinants in the mammalian embryo," Nature, Nature, vol. 585(7825), pages 404-409, September.
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