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J-shaped relationship between cardiovascular risk and efficacy of intensive blood pressure reduction: A post-hoc analysis of the SPRINT trial

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  • Armin Attar
  • Fatemeh Nouri
  • Roham Borazjani
  • Mehrab Sayadi

Abstract

Background: In the 2017 ACC/AHA hypertension guidelines, a 10-year risk of more than 10% is considered for initiation of intensive blood pressure reduction. The current study aimed to determine which cut off limit of cardiovascular risk for starting intensive blood pressure reduction is beneficial. Design: A Secondary Analysis of Systolic Blood Pressure Intervention Trial (SPRINT). Methods: Data from the SPRINT Trial was obtained from the NHLBI Data Repository Center. In the SPRINT, non-diabetic participants with SBP of ≥ 130 mmHg were randomly assigned to intensive and standard treatment arms with SBP targets of

Suggested Citation

  • Armin Attar & Fatemeh Nouri & Roham Borazjani & Mehrab Sayadi, 2020. "J-shaped relationship between cardiovascular risk and efficacy of intensive blood pressure reduction: A post-hoc analysis of the SPRINT trial," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0240102
    DOI: 10.1371/journal.pone.0240102
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