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Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis

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  • Chunmei Lin
  • Jinhao Liu
  • Hu Sun

Abstract

Purpose: A considerable number of diabetic foot ulcer (DFU) patients require amputation every year, which worsens their quality of life, aggravates the social burden, and shortens their life expectancy. Considering these negative effects, it is important to explore the relative risk factors affecting amputation in DFU patients. Methods: The PubMed, SCIE and Embase databases were comprehensively searched for prospective or retrospective studies published before October 31, 2019. All English language studies involving DFU patients were included, and RevMan 5.3 software was used to analyse the data. Results: This meta-analysis includes 21 studies involving 6505 participants, including 2006 patients who required a lower limb amputation. The following variables were associated with an increased risk of amputation: male sex (odds ratios (OR) = 1.30, 95% confidence interval (CI) = 1.16~1.46, P

Suggested Citation

  • Chunmei Lin & Jinhao Liu & Hu Sun, 2020. "Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0239236
    DOI: 10.1371/journal.pone.0239236
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    Cited by:

    1. Chia-Hui Tai & Tsung-Cheng Hsieh & Ru-Ping Lee & Shu-Fen Lo, 2021. "Prevalence and Medical Resource of Patients with Diabetic Foot Ulcer: A Nationwide Population-Based Retrospective Cohort Study for 2001–2015 in Taiwan," IJERPH, MDPI, vol. 18(4), pages 1-8, February.

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