IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0236778.html
   My bibliography  Save this article

Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease

Author

Listed:
  • Michael J Satlin
  • Parag Goyal
  • Reed Magleby
  • Grace A Maldarelli
  • Khanh Pham
  • Maiko Kondo
  • Edward J Schenck
  • Hanna Rennert
  • Lars F Westblade
  • Justin J Choi
  • Monika M Safford
  • Roy M Gulick

Abstract

Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are limited. Methods: This was a retrospective cohort study of hospitalized patients with COVID-19 who received ≥1 dose of HCQ at two New York City hospitals. We measured incident Grade 3 or 4 blood count and liver test abnormalities, ventricular arrhythmias, and vomiting and diarrhea within 10 days after HCQ initiation, and the proportion of patients who completed HCQ therapy. We also describe changes in Sequential Organ Failure Assessment hypoxia scores between baseline and day 10 after HCQ initiation and in-hospital mortality. Results: None of the 153 hospitalized patients with COVID-19 who received HCQ developed a sustained ventricular tachyarrhythmia. Incident blood count and liver test abnormalities occurred in

Suggested Citation

  • Michael J Satlin & Parag Goyal & Reed Magleby & Grace A Maldarelli & Khanh Pham & Maiko Kondo & Edward J Schenck & Hanna Rennert & Lars F Westblade & Justin J Choi & Monika M Safford & Roy M Gulick, 2020. "Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0236778
    DOI: 10.1371/journal.pone.0236778
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236778
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0236778&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0236778?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Clotilde Chatre & François Roubille & Hélène Vernhet & Christian Jorgensen & Yves-Marie Pers, 2018. "Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature," Drug Safety, Springer, vol. 41(10), pages 919-931, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nicholas Moore, 2020. "Chloroquine for COVID-19 Infection," Drug Safety, Springer, vol. 43(5), pages 393-394, May.
    2. Francesca Gorini & Kyriazoula Chatzianagnostou & Annamaria Mazzone & Elisa Bustaffa & Augusto Esposito & Sergio Berti & Fabrizio Bianchi & Cristina Vassalle, 2020. "“Acute Myocardial Infarction in the Time of COVID-19”: A Review of Biological, Environmental, and Psychosocial Contributors," IJERPH, MDPI, vol. 17(20), pages 1-17, October.
    3. Usman Abdulfatai & Adamu Uzairu & Gideon Adamu Shallangwa & Sani Uba, 2020. "Molecular Docking Analysis of Chloroquine and Hydroxychloroquine and Design of Anti-SARS-CoV2 Protease Inhibitor," Modern Applied Science, Canadian Center of Science and Education, vol. 14(10), pages 1-52, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0236778. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.