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Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout

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  • Fu-Shun Yen
  • Chih-Cheng Hsu
  • Hsin-Lun Li
  • James Cheng-Chung Wei
  • Chii-Min Hwu

Abstract

Objectives: Although studies have demonstrated the association of hyperuricemia with cardiovascular (CV) diseases, few have explored the effect of urate-lowering therapy (ULT) on the incidence of CV diseases. Therefore, we compared the risks of hospitalized coronary artery disease (CAD), stroke, heart failure (HF), and all-cause mortality between ULT users and nonusers among patients with gout. Methods: We performed this retrospective cohort study using Taiwan’s population-based National Health Insurance Research Database. In total, 5218 patients with gout were included from 2000 to 2012. We compared the incidence rates (IRs) of hospitalized CAD, stroke, HF, and all-cause mortality between ULT users and matched nonusers. Results: The IRs of hospitalized stroke were 0.6 and 1.0 per 100 person-years for ULT users and nonusers, respectively, after adjusting for age, sex, residence, comorbidities, and medications. ULT users showed lower adjusted hazard ratios (aHR) for hospitalized stroke (aHR: 0.52, p

Suggested Citation

  • Fu-Shun Yen & Chih-Cheng Hsu & Hsin-Lun Li & James Cheng-Chung Wei & Chii-Min Hwu, 2020. "Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0234909
    DOI: 10.1371/journal.pone.0234909
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    1. Jeremy G Wheeler & Kelsey D M Juzwishin & Gudny Eiriksdottir & Vilmundur Gudnason & John Danesh, 2005. "Serum Uric Acid and Coronary Heart Disease in 9,458 Incident Cases and 155,084 Controls: Prospective Study and Meta-Analysis," PLOS Medicine, Public Library of Science, vol. 2(3), pages 1-1, March.
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