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ATR-FTIR spectroscopy as adjunct method to the microscopic examination of hematoxylin and eosin-stained tissues in diagnosing lung cancer

Author

Listed:
  • Ruth Bangaoil
  • Abegail Santillan
  • Lara Mae Angeles
  • Lorenzo Abanilla
  • Antonio Lim Jr.
  • Ma Cristina Ramos
  • Allan Fellizar
  • Leonardo Guevarra Jr.
  • Pia Marie Albano

Abstract

Lung cancer remains the leading cause of cancer-related death worldwide. Since prognosis and treatment outcomes rely on fast and accurate diagnosis, there is a need for more cost-effective, sensitive, and specific method for lung cancer detection. Thus, this study aimed to determine the ability of ATR-FTIR in discriminating malignant from benign lung tissues and evaluate its concordance with H&E staining. Three (3) 5μm-thick sections were cut from formalin fixed paraffin embedded (FFPE) cell or tissue blocks from patients with lung lesions. The outer sections were H&E-stained and sent to two (2) pathologists to confirm the histopathologic diagnosis. The inner section was deparaffinized by standard xylene method and then subjected to ATR-FTIR analysis. Distinct spectral profiles that distinguished (p

Suggested Citation

  • Ruth Bangaoil & Abegail Santillan & Lara Mae Angeles & Lorenzo Abanilla & Antonio Lim Jr. & Ma Cristina Ramos & Allan Fellizar & Leonardo Guevarra Jr. & Pia Marie Albano, 2020. "ATR-FTIR spectroscopy as adjunct method to the microscopic examination of hematoxylin and eosin-stained tissues in diagnosing lung cancer," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0233626
    DOI: 10.1371/journal.pone.0233626
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