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The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib

Author

Listed:
  • Francesco Caputo
  • Vincenzo Dadduzio
  • Francesco Tovoli
  • Giulia Bertolini
  • Giuseppe Cabibbo
  • Krisida Cerma
  • Caterina Vivaldi
  • Luca Faloppi
  • Mario Domenico Rizzato
  • Fabio Piscaglia
  • Ciro Celsa
  • Lorenzo Fornaro
  • Giorgia Marisi
  • Fabio Conti
  • Nicola Silvestris
  • Marianna Silletta
  • Sara Lonardi
  • Alessandro Granito
  • Caterina Stornello
  • Valentina Massa
  • Giorgio Astara
  • Sabina Delcuratolo
  • Stefano Cascinu
  • Mario Scartozzi
  • Andrea Casadei-Gardini

Abstract

Background and aims: The present study aims to investigate the role of the prognostic nutritional index (PNI) on survival in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Methods: This multicentric study included a training cohort of 194 HCC patients and three external validation cohorts of 129, 76 and 265 HCC patients treated with Sorafenib, respectively. The PNI was calculated as follows: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm3). Univariate and multivariate analyses were performed to investigate the association between the covariates and the overall survival (OS). Results: A PNI cut-off value of 31.3 was established using the ROC analysis. In the training cohort, the median OS was 14.8 months (95% CI 12–76.3) and 6.8 months (95% CI 2.7–24.6) for patients with a high (>31.3) and low ( 70 years (p 31.3 was found to be an independent prognostic factor for predicting OS in all the three validation cohorts. Conclusions: PNI represents a prognostic tool in advanced HCC treated with first-line Sorafenib. It is readily available and low-cost, and it could be implemented in clinical practice in patients with HCC.

Suggested Citation

  • Francesco Caputo & Vincenzo Dadduzio & Francesco Tovoli & Giulia Bertolini & Giuseppe Cabibbo & Krisida Cerma & Caterina Vivaldi & Luca Faloppi & Mario Domenico Rizzato & Fabio Piscaglia & Ciro Celsa , 2020. "The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0232449
    DOI: 10.1371/journal.pone.0232449
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