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Hydroxyapatite-coated implants provide better fixation in total knee arthroplasty. A meta-analysis of randomized controlled trials

Author

Listed:
  • Tamara Horváth
  • Lilla Hanák
  • Péter Hegyi
  • Edina Butt
  • Margit Solymár
  • Ákos Szűcs
  • Orsolya Varga
  • Bui Quoc Thien
  • Zsolt Szakács
  • Endre Csonka
  • Petra Hartmann

Abstract

Background: The potential advantages of hydroxyapatite (HA)-coated cementless total knee arthroplasty (TKA) implants are bone stock preservation and biological fixation. Studies comparing the outcomes of HA-coated cementless, non HA-coated cementless (uncemented) and cemented TKA implants reported contradictory data. Our aim was to provide a comparison of the effects of HA coating of tibial stem on the stability and functionality of TKA implants. Methods: A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the CENTRAL databases up to May 31st, 2019. The primary outcome was Maximum Total Point Motion (MTPM) of the tibial stem. This parameter is determined by radiosterometric analysis and refers to the migration pattern of the prosthesis stems. The clinical outcomes of the implanted joints were evaluated by the Knee Society Knee Score (KSS) and the Knee Society Function Score (KFS). Weighted mean difference (WMD) with 95% confidence interval (CI) were calculated with the random-effects model. Results: Altogether, 11 randomized controlled trials (RCTs) with 902 patients for primary TKA implants were included. There was a statistically significant difference in the MTPM values with the use of HA-coated and uncoated uncemented implants (WMD = +0.28, CI: +0.01 to +0.56, P

Suggested Citation

  • Tamara Horváth & Lilla Hanák & Péter Hegyi & Edina Butt & Margit Solymár & Ákos Szűcs & Orsolya Varga & Bui Quoc Thien & Zsolt Szakács & Endre Csonka & Petra Hartmann, 2020. "Hydroxyapatite-coated implants provide better fixation in total knee arthroplasty. A meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0232378
    DOI: 10.1371/journal.pone.0232378
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