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Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012–2013 and 2018–2019

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Listed:
  • Hidetoshi Nomoto
  • Masahiro Ishikane
  • Takato Nakamoto
  • Masayuki Ohta
  • Shinichiro Morioka
  • Kei Yamamoto
  • Satoshi Kutsuna
  • Shunsuke Tezuka
  • Junwa Kunimatsu
  • Norio Ohmagari

Abstract

Background: Rubella virus infection mainly causes illness with mild fever, rash, and lymphadenopathy in children; however, the clinical characteristics of adult rubella are not well-known. Methods: An observational study was conducted to compare the characteristics between adult rubella and adult non-rubella among participants aged ≥18 years, with suspected symptomatic rubella. Participants were screened for rubella-specific IgM expression using an enzyme immune assay kit, at a tertiary care hospital in Japan during two outbreaks (January 2012–December 2013 and January 2018–March 2019). Adult rubella diagnosis followed strong positive or paired rubella-specific IgM expression or positive rubella-specific reverse-transcription-polymerase chain reaction. Patients aged

Suggested Citation

  • Hidetoshi Nomoto & Masahiro Ishikane & Takato Nakamoto & Masayuki Ohta & Shinichiro Morioka & Kei Yamamoto & Satoshi Kutsuna & Shunsuke Tezuka & Junwa Kunimatsu & Norio Ohmagari, 2020. "Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012–2013 and 2018–2019," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0231966
    DOI: 10.1371/journal.pone.0231966
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