IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0230815.html
   My bibliography  Save this article

Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose

Author

Listed:
  • Peitao Wu
  • Denis Rybin
  • Lawrence F Bielak
  • Mary F Feitosa
  • Nora Franceschini
  • Yize Li
  • Yingchang Lu
  • Jonathan Marten
  • Solomon K Musani
  • Raymond Noordam
  • Sridharan Raghavan
  • Lynda M Rose
  • Karen Schwander
  • Albert V Smith
  • Salman M Tajuddin
  • Dina Vojinovic
  • Najaf Amin
  • Donna K Arnett
  • Erwin P Bottinger
  • Ayse Demirkan
  • Jose C Florez
  • Mohsen Ghanbari
  • Tamara B Harris
  • Lenore J Launer
  • Jingmin Liu
  • Jun Liu
  • Dennis O Mook-Kanamori
  • Alison D Murray
  • Mike A Nalls
  • Patricia A Peyser
  • André G Uitterlinden
  • Trudy Voortman
  • Claude Bouchard
  • Daniel Chasman
  • Adolfo Correa
  • Renée de Mutsert
  • Michele K Evans
  • Vilmundur Gudnason
  • Caroline Hayward
  • Linda Kao
  • Sharon L R Kardia
  • Charles Kooperberg
  • Ruth J F Loos
  • Michael M Province
  • Tuomo Rankinen
  • Susan Redline
  • Paul M Ridker
  • Jerome I Rotter
  • David Siscovick
  • Blair H Smith
  • Cornelia van Duijn
  • Alan B Zonderman
  • D C Rao
  • James G Wilson
  • Josée Dupuis
  • James B Meigs
  • Ching-Ti Liu
  • Jason L Vassy

Abstract

Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies from the Cohorts for Heart Aging Research in Genomic Epidemiology Consortium (n = 74,584). In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p

Suggested Citation

  • Peitao Wu & Denis Rybin & Lawrence F Bielak & Mary F Feitosa & Nora Franceschini & Yize Li & Yingchang Lu & Jonathan Marten & Solomon K Musani & Raymond Noordam & Sridharan Raghavan & Lynda M Rose & K, 2020. "Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-17, May.
    • Handle: RePEc:plo:pone00:0230815
    DOI: 10.1371/journal.pone.0230815
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230815
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0230815&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0230815?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0230815. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.