IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0230512.html
   My bibliography  Save this article

The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review

Author

Listed:
  • Sarah Elshahat
  • Paul Cockwell
  • Alexander P Maxwell
  • Matthew Griffin
  • Timothy O’Brien
  • Ciaran O’Neill

Abstract

Chronic kidney disease (CKD) affects over 10% of the global population and poses significant challenges for societies and health care systems worldwide. To illustrate these challenges and inform cost-effectiveness analyses, we undertook a comprehensive systematic scoping review that explored costs, health-related quality of life (HRQoL) and life expectancy (LE) amongst individuals with CKD. Costs were examined from a health system and societal perspective, and HRQoL was assessed from a societal and patient perspective. Papers published in English from 2015 onward found through a systematic search strategy formed the basis of the review. All costs were adjusted for inflation and expressed in US$ after correcting for purchasing power parity. From the health system perspective, progression from CKD stages 1–2 to CKD stages 3a-3b was associated with a 1.1–1.7 fold increase in per patient mean annual health care cost. The progression from CKD stage 3 to CKD stages 4–5 was associated with a 1.3–4.2 fold increase in costs, with the highest costs associated with end-stage renal disease at $20,110 to $100,593 per patient. Mean EuroQol-5D index scores ranged from 0.80 to 0.86 for CKD stages 1–3, and decreased to 0.73–0.79 for CKD stages 4–5. For treatment with renal replacement therapy, transplant recipients incurred lower costs and demonstrated higher HRQoL scores with longer LE compared to dialysis patients. The study has provided a comprehensive updated overview of the burden associated with different CKD stages and renal replacement therapy modalities across developed countries. These data will be useful for the assessment of new renal services/therapies in terms of cost-effectiveness.

Suggested Citation

  • Sarah Elshahat & Paul Cockwell & Alexander P Maxwell & Matthew Griffin & Timothy O’Brien & Ciaran O’Neill, 2020. "The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-19, March.
  • Handle: RePEc:plo:pone00:0230512
    DOI: 10.1371/journal.pone.0230512
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230512
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0230512&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0230512?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Mark D Jesky & Mary Dutton & Indranil Dasgupta & Punit Yadav & Khai Ping Ng & Anthony Fenton & Derek Kyte & Charles J Ferro & Melanie Calvert & Paul Cockwell & Stephanie J Stringer, 2016. "Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-18, November.
    2. Claudio Jommi & Patrizio Armeni & Margherita Battista & Paolo Procolo & Giuseppe Conte & Claudio Ronco & Mario Cozzolino & Anna Maria Costanzo & Umberto Luzio Paparatti & Gabriella Concas & Giuseppe R, 2018. "The Cost of Patients with Chronic Kidney Failure Before Dialysis: Results from the IRIDE Observational Study," PharmacoEconomics - Open, Springer, vol. 2(4), pages 459-467, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Benjamin R Fletcher & Sarah Damery & Olalekan Lee Aiyegbusi & Nicola Anderson & Melanie Calvert & Paul Cockwell & James Ferguson & Mike Horton & Muirne C S Paap & Chris Sidey-Gibbons & Anita Slade & N, 2022. "Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis," PLOS Medicine, Public Library of Science, vol. 19(4), pages 1-25, April.
    2. Nga T Q Nguyen & Paul Cockwell & Alexander P Maxwell & Matthew Griffin & Timothy O’Brien & Ciaran O’Neill, 2018. "Chronic kidney disease, health-related quality of life and their associated economic burden among a nationally representative sample of community dwelling adults in England," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-12, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0230512. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.