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lillies: An R package for the estimation of excess Life Years Lost among patients with a given disease or condition

Author

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  • Oleguer Plana-Ripoll
  • Vladimir Canudas-Romo
  • Nanna Weye
  • Thomas M Laursen
  • John J McGrath
  • Per Kragh Andersen

Abstract

Life expectancy at a given age is a summary measure of mortality rates present in a population (estimated as the area under the survival curve), and represents the average number of years an individual at that age is expected to live if current age-specific mortality rates apply now and in the future. A complementary metric is the number of Life Years Lost, which is used to measure the reduction in life expectancy for a specific group of persons, for example those diagnosed with a specific disease or condition (e.g. smoking). However, calculation of life expectancy among those with a specific disease is not straightforward for diseases that are not present at birth, and previous studies have considered a fixed age at onset of the disease, e.g. at age 15 or 20 years. In this paper, we present the R package lillies (freely available through the Comprehensive R Archive Network; CRAN) to guide the reader on how to implement a recently-introduced method to estimate excess Life Years Lost associated with a disease or condition that overcomes these limitations. In addition, we show how to decompose the total number of Life Years Lost into specific causes of death through a competing risks model, and how to calculate confidence intervals for the estimates using non-parametric bootstrap. We provide a description on how to use the method when the researcher has access to individual-level data (e.g. electronic healthcare and mortality records) and when only aggregated-level data are available.

Suggested Citation

  • Oleguer Plana-Ripoll & Vladimir Canudas-Romo & Nanna Weye & Thomas M Laursen & John J McGrath & Per Kragh Andersen, 2020. "lillies: An R package for the estimation of excess Life Years Lost among patients with a given disease or condition," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-18, March.
  • Handle: RePEc:plo:pone00:0228073
    DOI: 10.1371/journal.pone.0228073
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    References listed on IDEAS

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    1. Per Kragh Andersen & Vladimir Canudas-Romo & Niels Keiding, 2013. "Cause-specific measures of life years lost," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 29(41), pages 1127-1152.
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