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Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer

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  • Zhenjiang Zheng
  • Mojin Wang
  • Chunlu Tan
  • Yonghua Chen
  • Jie Ping
  • Rui Wang
  • Xubao Liu

Abstract

Background: The survival of pancreatic cancer patients with lesions in different locations is unclear. In addition, the different surgery types for nonmetastatic pancreatic head cancer (PHC) or body/tail cancer (PBTC) have different prognostic influences. We analyzed the association by stage between tumor location (head vs. body/tail) and survival of nonmetastatic pancreatic cancer patients who underwent surgery. Methods: We identified stages I to III pancreatic cancer patients who underwent surgery from 2004 through 2015 by using the Surveillance, Epidemiology, and End Results (SEER) database. The adjusted hazard ratio (HR) and 95% confidence interval (CI) for cancer-specific survival (CSS) were obtained using Cox regression. Results: A total of 13517 patients or 86.6% had PHC. PHC patients were more likely to have an advanced tumor stage, higher tumor grade, and more frequent and a higher number of positive lymph nodes compared with PBTC patients. The PHC patients had a worse CSS than PBTC patients (P

Suggested Citation

  • Zhenjiang Zheng & Mojin Wang & Chunlu Tan & Yonghua Chen & Jie Ping & Rui Wang & Xubao Liu, 2019. "Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0226726
    DOI: 10.1371/journal.pone.0226726
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