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Association between circulating neuregulin4 levels and diabetes mellitus: A meta-analysis of observational studies

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  • Yao Wang
  • Shuai Huang
  • Pei Yu

Abstract

Introduction: Neuregulin 4 (Nrg4) was proven as a brown fat-enriched secreted factor that can regulate glucose and lipid metabolism. However, the association between circulating Nrg4 levels and diabetes mellitus (DM) in human remains unclear. We conducted a meta-analysis to investigate association of circulating Nrg4 with DM. Methods: Observational studies comparing circulating Nrg4 levels in diabetes patients and health controls were included. Circulating Nrg4, correlation coefficients of clinical indices and circulating Nrg4 were pooled by meta-analysis. Results: Seven studies were included. The pooled results indicated there were no significant difference in the circulating Nrg4 between diabetes patients and controls (SMD = 0.18, 95%CI = -0.06 to 0.42, P = 0.143). However, diabetes patients had higher circulating Nrg4 than their controls in cross-sectional studies (SMD = 0.55, 95%CI = 0.36 to 0.73, P

Suggested Citation

  • Yao Wang & Shuai Huang & Pei Yu, 2019. "Association between circulating neuregulin4 levels and diabetes mellitus: A meta-analysis of observational studies," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0225705
    DOI: 10.1371/journal.pone.0225705
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