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Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study

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  • Eliza Lai yi Wong
  • Richard Huan Xu
  • Annie Wai ling Cheung

Abstract

Objectives: The aims of this study were to 1) evaluate the impact of eight common chronic conditions and multimorbidity on preference-based health-related quality of life (HRQoL), and 2) estimate the minimally important difference (MID) in the general population of Hong Kong (HK). Design: Data were analyzed using secondary data analysis based on a cross-sectional, population-based validation study of HK’s general population. Participants: A representative sample was recruited across eighteen geographical districts in HK, and 1,014 HK Chinese residents aged 18 years and older participated in the survey. The prevalence of chronic conditions among the respondents was 30.3%. Interventions: The HRQoL was assessed using the locally validated version of EQ-5D-5L. The five-dimension descriptive system, and the utility scores of EQ-5D-5L were used as the dependent variable in the study. Eight common chronic conditions, multimorbidity, and demographic characteristics were defined as predictors in the analysis. Chi-squared test, analysis of variance (ANOVA), logistic regression, and Tobit regression models were used to analyze the data. A simulation-based approach was used to calculate the MID based on instrument-defined single level transitions. Results: The findings indicated that respondents with physical disabilities were more likely to report problems on all five dimensions of the EQ-5D-5L than those with other chronic conditions. In addition, respondents with multiple chronic conditions were more likely to report health problems and lower utility scores of EQ-5D-5L. The mean of MID estimates among the respondents in HK was 0.093 (standard deviation = 0.001), which is higher than in other Asian countries. Conclusions: The findings suggest that having more chronic conditions is strongly associated with a lower HRQoL. Healthcare reforms to address foreseeable challenges arising as more patients live with chronic conditions and multimorbidity could improve the HRQoL of HK citizens.

Suggested Citation

  • Eliza Lai yi Wong & Richard Huan Xu & Annie Wai ling Cheung, 2019. "Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-16, November.
    • Handle: RePEc:plo:pone00:0224970
    DOI: 10.1371/journal.pone.0224970
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    1. Valentin Walker & Christine Perret-Guillaume & Emmanuelle Kesse-Guyot & Nelly Agrinier & Serge Hercberg & Pilar Galan & Karen E Assmann & Serge Briançon & Christine Rotonda, 2016. "Effect of Multimorbidity on Health-Related Quality of Life in Adults Aged 55 Years or Older: Results from the SU.VI.MAX 2 Cohort," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-15, December.
    2. Roger Y Chung & Stewart Mercer & Francisco T T Lai & Benjamin H K Yip & Martin C S Wong & Samuel Y S Wong, 2015. "Socioeconomic Determinants of Multimorbidity: A Population-Based Household Survey of Hong Kong Chinese," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-15, October.
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    1. Richard Huan Xu & Yi Dai & Shamay S. M. Ng & Hector W. H. Tsang & Shuyang Zhang & Dong Dong, 2024. "Assessing validity of the EQ-5D-5L proxy in children and adolescents with Duchenne muscular dystrophy or spinal muscular atrophy," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 25(1), pages 103-115, February.

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